chinese-scientists-develop-hydrogel-for-arthritis-report

Chinese scientists have announced a breakthrough in treating osteoarthritis, a common form of arthritis, with a new advanced lubricating material.

 

The development, revealed in a press release from the Chinese Academy of Sciences (CAS) last Wednesday, promises to slow the disease’s progression, particularly in its early stages.

 

The new material, detailed in the peer-reviewed journal *Advanced Materials* on August 18, targets damaged cartilage with enhanced lubrication.

 

The study was led by researchers Li Jiusheng and Lu Hengyi from the CAS Shanghai Advanced Research Institute, in collaboration with spine surgery and orthopaedics clinician Wang Yunjia of Xiangya Government Hospital in Changsha.

 

Osteoarthritis, which affects joints including the knees, hips, spine, and hands, involves the degeneration of cartilage leading to pain, swelling, and reduced mobility. The reduced lubrication of cartilage is a key factor in the onset of the disease.

 

The newly developed material comprises hydrogel microspheres, which are tiny, hollow particles used in tissue repair. These microspheres are made from gelatin methacrylate—a biomaterial derived from collagen—and poly(sulfobetaine methacrylate) (PSBMA), a polymer known for its hydration properties.

 

 The researchers have also created an antibody that targets injured cartilage and attaches to the microspheres for enhanced precision in treatment.

 

In tests with rats exhibiting early-stage osteoarthritis, the material significantly slowed disease progression and alleviated symptoms.

 

It also demonstrated superior lubrication, reducing the average coefficient of friction by more than half compared to standard saline treatments, and more than a third compared to conventional bio-lubricants.

 

This advancement represents a promising and convenient technique for managing osteoarthritis, especially in its early stages.

 

 With osteoarthritis affecting approximately 528 million people worldwide in 2019—a 113 per cent increase since 1990—the new material could offer a significant improvement in treatment options.

 

The World Health Organisation (WHO) has highlighted the growing prevalence of osteoarthritis, driven by ageing populations, obesity, and joint injuries.

 

The new development offers hope for better management and treatment of this debilitating condition.