The Palestinian Health Ministry reported a devastating toll from an Israeli assault on shelters in Gaza's al-Mawasi area, designated by Israel as a humanitarian safe zone, on Saturday.
At least 25 people were killed and 50 wounded in the attack, with no clarification yet issued by the Israeli government regarding the latest killings.
The World Health Organization (WHO) described the health system in Gaza as on the brink of collapse due to the influx of casualties from the assault on the supposed safe zone, flooding Al-Aqsa Hospital.
In a separate incident on Friday, Israeli strikes resulted in the deaths of at least 45 Palestinians and left dozens more injured.
Israeli tanks advanced further into western Rafah amidst continuous bombardment by warplanes and artillery.
The escalation followed the destruction of an Israeli armoured vehicle by an improvised explosive device planted by Hamas.
Since October 7, the conflict has claimed the lives of at least 37,431 people in Gaza, with 85,653 others wounded.
In Israel, the death toll from Hamas-led attacks now stands at 1,139, with several individuals still held captive in Gaza.